Research Article

Neonatal AKI Profile Using KDIGO Guidelines: A Cohort Study in Tertiary Care Hospital ICU of Lahore, Pakistan

Rafia Gul, Zahid Anwar, Mehmood Sheikh, Ayesha Salamat, Samer Iqbal, Furqan Saleem, Samer Fatima

Frontiers in Pediatrics · Vol. 10 · Article 1040077 · Published December 7, 2022 · DOI: 10.3389/fped.2022.1040077

iD ORCID iD: https://orcid.org/0000-0002-0605-7089 · View All Publications by Dr. Rafia Gul

In Brief

Acute kidney injury (AKI) is a sudden drop in kidney function that can affect sick newborns and is linked to poor outcomes. This study used the neonatal KDIGO criteria to find out how many babies in a neonatal intensive care unit (NICU) developed AKI, which babies were at higher risk, and how AKI affected survival.

Key Points

• A cohort study in the NICU of Fatima Memorial Hospital, Lahore, from June 2019 to May 2021, including 1,258 sick newborns.
• AKI occurred in 473 babies (37.6%): 15.7% had stage 1, 16.3% stage 2 and 5.6% stage 3.
• The strongest risk factors were being born outside the hospital (outborn), birth asphyxia, use of inotropic medicines, antenatal steroids, central lines, and brain bleeding or clotting problems (IVH/ICH/DIC).
• Mortality was 16.5% in babies with AKI compared with 3.9% in babies without it, and AKI was linked to a longer hospital stay.

AKISick NeonatesSurvivalOutbornBirth AsphyxiaKDIGO

Published in Frontiers in Pediatrics (Neonatology), Vol. 10 (2022), Original Research. PDF shared by the authors.