Research Article

Spectrum and Antimicrobial Susceptibility Pattern of Micro-Organisms Associated With Neonatal Sepsis in a Hospital in Karachi, Pakistan

Mehmood Shaikh, Muhammad Hanif, Rafia Gul, Wajid Hussain, Hemandas Hemandas, Ashraf Memon

Cureus · Vol. 12, No. 10 · Article e10924 · Published October 13, 2020 · DOI: 10.7759/cureus.10924

iD ORCID iD: https://orcid.org/0000-0002-0605-7089 · View All Publications by Dr. Rafia Gul

In Brief

Sepsis, a serious bloodstream infection, is a major cause of illness and death in newborns, and choosing the right antibiotic quickly is vital. This study looked at which germs caused sepsis in newborns at a hospital in Karachi and which antibiotics were still effective against them.

Key Points

• A study in the Neonatology Unit of Kharadar General Hospital, Karachi, of 162 newborns with suspected sepsis and a positive blood culture. Of these, 106 (65.4%) were boys.
• Gram-positive bacteria caused 83 cases and Gram-negative bacteria 79 cases. Staphylococcus aureus was the most common germ (about half of cases), followed by Pseudomonas (25.7%).
• Gram-positive germs were mostly sensitive to amikacin and vancomycin.
• Gram-negative germs were mostly sensitive to amikacin, imipenem, meropenem and ciprofloxacin.

NeonatesSepsisCausative BacteriaAntimicrobial Sensitivity

Published in Cureus, Vol. 12, No. 10 (October 2020). PDF shared by the authors.